Spain recognized Lithuania de jure on 27 July 1922.
Spain recognized the re-establishment of the State of Lithuania de jure on 27 August 1991.
Diplomatic relations were re-established on 7 October 1991.
From 1992 to 1994, Osvaldas Balakauskas served as the first Ambassador of Lithuania to Spain after the re-establishment of independence (resided in France).
From 1992 to 1993, Carlos Fernandez-Longoria y Pavia served as the first Ambassador of Spain to Lithuania (resided in Denmark).